Thursday, August 22 2019

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Two Ebola drugs found to increase survival rates

Update: August, 13/2019 - 10:14

 

A girl receives a vaccine against Ebola from a nurse in Goma on August 7. — AFP Photo

WASHINGTON — Scientists were a step closer to an effective treatment for Ebola after two drugs in a clinical trial were found to significantly boost survival rates, the US health authority co-funding the research said Monday.

The study began last November in the Democratic Republic of Congo, but its current phase has been halted and all future patients switched over to the treatments that have shown positive results, the US National Institutes of Health (NIH) said in a statement.

REGN-EB3 and mAb114 "are the first drugs that, in a scientifically sound study, have clearly shown a significant diminution in mortality for people with Ebola virus disease," Anthony Fauci, director of the NIH's National Institute of Allergy and Infectious Diseases, told AFP.

Patients who were receiving two other drugs that are being discontinued, Zmapp and remdesivir, will now have the option at the discretion of their treating physician to receive the treatments that have been shown to work.

Fauci explained that the trial was designed to include 725 people, but was halted by an independent board when it had enrolled 681 people because at that point, one of the drugs, REGN-EB3 by Regeneron, reached a critical threshold in success, while mAb114 was not far behind.

Data has so far been analyzed for 499 people from the cohort of 681. 

In this group, mortality dropped to 29 per cent with REGN-EB3 and with mAb114 it fell to 34 per cent, said Fauci – compared to a rate of between 60 and 67 per cent in the general population when the disease is not treated by a drug.

The rates for Zmapp and remdesivir were 49 per cent and 53 per cent respectively.

REGN-EB3, mAb114 and Zmapp are monoclonal antibodies that bind to glycoprotein on the Ebola virus and neutralise its ability to infect other cells. 

Fauci added that the final analysis of the data, including the patients not yet processed, would occur in late September or early October, after which the complete results would be submitted for publication in peer-reviewed medical literature.

The NIH, Democratic Republic of Congo health authorities and the World Health Organisation hailed the "extraordinary team of individuals who have worked under extremely difficult conditions to carry out this study," as well as the patients and their families. — AFP

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