VISSO — Two strong earthquakes rocked central Italy on Wednesday, toppling buildings and injuring dozens of people according to initial reports, two months after a devastating tremor killed nearly 300 in the same region.

The first 5.5 magnitude quake sent people running out of their houses, likely saving lives when the second, more destructive, 6.1 magnitude one struck two hours later.

But rescuers working through the night and in the rain were struggling to assess the full extent of the disaster.

"Many houses have collapsed. Our town is finished," Marco Rinaldi, mayor of the mountain town of Ussita, told Sky Italy television by telephone.

"The second quake was a long, terrible one," he said.

"I’ve felt a lot of earthquakes but that was the strongest I’ve ever felt.

Fortunately everyone had already left their homes after the first quake so I don’t think anyone was hurt."

Several dozen people were treated for light injuries or shock, civil protection chief Fabrizio Curcio told a late night press conference, but no serious injuries had been reported.

"Ultimately, the situation is not as catastrophic as might have been expected" given the strength of the tremors, he said.

The quakes were felt in the capital Rome, sending residents running out of their houses and into the streets. The second was felt as far away as Venice in the far north, and Naples, south of the capital.

The US Geological Survey (USGS) registered a first 5.5-magnitude quake at 1710 GMT, with the second two hours later. In both cases the epicentre was near the village of Visso in the central Marche region.

In August, a 6.0-6.2 magnitude quake flattened the mountain town of Amatrice -- 70 kilometres from Visso -- killing 297 people and injuring hundreds of others.

After the second quake, Italian television channels broadcast images of collapsed buildings and people standing dazed in front of their toppled houses.

"It is not very easy to make assessments in the dark and the weather is bad in the whole region. We will have to see more precisely in the light of day," said Curcio.

For people who are unable to return home immediately, civil protection has arranged accommodation in gyms and prepared to reopen some of the tent camps which were set up after the August earthquake. Many residents prepared to spend the night in their cars.

"I want to thank those working in the rain in the earthquake zones. All of Italy is wrapping its arms around the communities that have been hit once again," Prime Minister Matteo Renzi tweeted.

In Rome, the quakes rattled windows and doors. The imposing foreign ministry headquarters was temporarily evacuated.

A Serie A football match between Pescara and Atalanta was halted for several minutes when the first tremor hit.

Italy’s national geophysics institute said the latest quakes were linked to the August one, which was followed by thousands of aftershocks, some of them very strong.

"Aftershocks can last for a long time, sometimes for months," geologist Mario Tozzi said.

August’s disaster caused an estimated four billion euros ($4.5 billion) of damage, with 1,400 people still living in temporary accommodation.

Around two-thirds of the deaths occurred in Amatrice, a beauty spot and popular tourist destination packed with holiday-makers when the quake struck at the height of the summer season. — AFP